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Foodborne illnesses, particularly those caused by Salmonella spp., represent a major global health concern, with S. typhimurium being a significant contributor to outbreaks. The persistence of S. typhimurium in food production environments and its resistance to conventional disinfectants highlight the need for alternative antimicrobial solutions. Essential oils (EOs) from Eucalyptus globulus (EGEO) and Cymbopogon flexuosus (CF...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Adapting Species Risk Assessments to a Changing Climate: The Underestimated Vulnerability of Foundational TreesNARA Subscribed
Climate change is one of the top threats to biodiversity. However, many species risk assessment frameworks, including the globally authoritative International Union for Conservation of Nature Red List, do not consistently and comprehensively incorporate loss of climatically suitable habitat into listing or threat categorization decisions. Using California's foundational, endemic and near‐endemic trees as an exemplary set of hi...
Decoupled Climatic Drivers of Tree and Ground‐Layer Carbon Uptake in Mountain Ecosystems Around the WorldNARA Subscribed
One of the key ecological processes affected by climate change is plant carbon uptake. However, there is substantial uncertainty about how plant carbon uptake will respond to warming in mountain ecosystems, which are known for sharp temperature gradients and abrupt shifts in vegetation structure. Specifically, we lack an understanding of whether these response trajectories over time will be linear or non‐linear, and how they m...
Diagnosing scaling bottlenecks in 10 community conservation initiatives in southern and eastern AfricaNARA Subscribed
Scaling area‐based conservation, including initiatives led or comanaged by Indigenous Peoples and local communities, is a flagship goal of the Kunming‐Montreal Global Biodiversity Framework. Conservationists often aspire to scale initiatives, but this is rarely achieved in practice. Identifying and addressing factors that limit initiative adoption (i.e., bottlenecks) could improve scaling strategies. We used insightsfrom 84 ex...
This study investigates the effects of environmentally relevant concentrations of atrazine and fluoxetine, both individually and in combination, on aggressive behavior in male Betta splendens (B. splendens). Controlled behavioral assays were used to test the hypothesis that both individual and combined exposures would alter aggressive behavior, primarily by delaying the initiation of aggression and reducing the duration of spe...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...