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Validation and marker development for a chromosome 2 QTL for fire blight resistance in pearNARA Subscribed
Fire blight, caused by the bacterial pathogen Erwinia amylovora , is a persistent problem for pear ( Pyrus spp.) growers across most production regions around the world. Growing resistant cultivars is one of the best options for managing fire blight. The resistant P. communis cultivars ‘Potomac’ and ‘Old Home’, and the hybrid selection NJA2R59T69 were used in a previous study to identify quantitative trait loci (QTLs) linked t...
Urchin diets are a topic of global interest due to their impacts on subtidal reefs. Urchins can consume large amounts of macroalgae, leading to the loss of macroalgal forests and creation of “barrens”. However, there is scant dietary information in the southern hemisphere for the temperate sea urchin, Centrostephanus rodgersii , and what they consume within barrens, which lack macroalgae. Here, we sampled C. rodgersii to quant...
Bio‐oceanographic modeling and population genomics were combined to assess connectivity of the blue crab Callinectes sapidus in the Southwestern Atlantic Ocean, with particular attention to the scale of its fishery management, and the potential role of Marine Protected Areas (MPAs) in Uruguay as larval source zones. A bio‐physical model, coupled with hydrodynamic outputs of a model experiment, incorporated larval vertical migr...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Distribution, scale, and drivers of mass mortality events in Europe's freshwater bivalvesNARA Subscribed
Mass mortality events (MMEs) are decimating populations and compromising key ecosystem functions around the globe. One taxon particularly vulnerable to MMEs is freshwater bivalve mollusks. This group has important ecosystem engineering capacities and includes highly threatened and highly invasive taxa. Thus, MMEs of freshwater bivalves have important implications for conservation and ecosystems. Despite this, little is known a...