Reliable operation of adjustable ballast systems is essential for full-ocean-depth manned submersibles, but existing studies mostly focus on component-level performance optimization, leaving the multi-valve coupled instability mechanism under ultra-high pressure insufficiently understood. This paper investigates an uncontrolled water injection failure in the adjustable ballast system of the “Fendouzhe” submersible via fault tr...

A potential use of small extracellular vesicles (sEVs) for diagnostic and therapeutic purposes has recently generated a great interest. sEVs, when purified directly from various tissues with proper procedures, can reflect the physiological and pathological state of the organism. However, the quality of sEV is affected by many factors during isolation, including separation of sEV from cell and tissues debris, the use of enzymes...