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Springer Nature1
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The AAPS Journal1
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20211
Derrick Chatad results 1 · Newest (Page 1/1, per page 25)
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The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2NARA Subscribed
The AAPS Journal · 2021 · Vol. 23 · Issue 2 · Springer
Osatohanmwen J. Enogieru; Megan L. Koleske; Bianca Vora; Huy Ngo; Sook Wah Yee; Derrick Chatad; Marina Sirota; Kathleen M. Giacomini
A rare cause of megaloblastic anemia (MA) is thiamine-responsive megaloblastic anemia (TRMA), a genetic disorder caused by mutations in SLC19A2 (encoding THTR1), a thiamine transporter. The study objectives were to (1) functionally characterize selected TRMA-associated SLC19A2 variants and (2) determine whether current prescription drugs associated with drug-induced MA (DIMA) may act via inhibition of SLC19A2. Functional chara...
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