We reported previously that diet-induced obesity exacerbates early-stage Alzheimer’s disease (AD)–like pathology in TgF344-AD rats. Those findings also suggested that they may be prone to weight gain during early AD development, raising the possibility of early hypothalamic dysfunction. In this study, we investigate this by determining whether hypothalamic soluble amyloid-β 40 (Aβ 40 ) and amyloid-β 42 (Aβ 42 ) are detectable...