In previous studies, we demonstrated the involvement of H 4 R in inflammatory bowel disease (IBD) and IBD-associated colon cancer in mice and could ascribe H 4 R-mediated histamine function to colon epithelial cells. The transferability of obtained data to humans is however lacking. Functional expression of H 4 R on colon epithelial cells is a prerequisite to pursue the hypothesis of involvement of H 4 R in carcinogenesis. Thu...