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The DNA Demethylase TET1 is a Pivotal Regulator of the miR-124/ISX9-Instructed Conversion of Astrocytes to Induced NeuronsNARA Subscribed
The microRNA miR-124 promotes neuronal identity by acting globally, through its multiple targets, at the epigenetic, transcriptional and post-transcriptional levels. We have previously shown that miR-124 acts as a potent driver of the astrocytic fate switch toward an immature neuronal identity, while its supplementation with the neurogenic compound ISX9 enhances in vitro neuronal maturation. Nevertheless, additional cues are n...
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