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The negative and cognitive symptoms of schizophrenia are predictive of quality of life and functional recovery, but there are no approved drug options that target these symptoms directly. TAK-041 (also known as NBI-1065846) is a selective and potent small-molecule agonist of GPR139, an orphan G-protein-coupled receptor, which has been shown to reverse deficits related to negative and cognitive symptoms in animal models. In thi...
Mediterranean mountainous areas and their valuable natural resources have long been attractive to human societies. The Peloponnese (southern Greece), with its complex topographic and climatic variability, has been the scenery for the development of numerous human communities. The existing paleovegetation records from the region derive mainly from lowland sites, while the vegetation succession of the mountains is not clearly un...
Paclitaxel-loaded elastic liposomes synthesised by microfluidics technique for enhance transdermal deliveryNARA Subscribed
The inherent flexibility of elastic liposomes (EL) allows them to penetrate the small skin pores and reach the dermal region, making them an optimum candidate for topical drug delivery. Loading chemotherapy in ELs could improve chemotherapy’s topical delivery and localise its effect on skin carcinogenic tissues. Chemotherapy-loaded EL can overcome the limitations of conventional administration of chemotherapies and control the...
Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletesNARA Subscribed
Purpose Recombinant human erythropoietin (rHuEPO) is known to increase thrombotic risk in patients and might have similar effects in athletes abusing the drug. rHuEPO is prohibited by anti-doping legislation, but this risk has not been investigated thoroughly. This analysis was designed to evaluate whether rHuEPO impacts hemostatic profile and endothelial and platelet activation markers in trained subjects, and whether the com...
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