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NARA Subscribed1
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Springer Nature1
Journal
Psychopharmacology1
Publication Year
20261
Dimitrios Arkilo results 1 · Newest (Page 1/1, per page 25)
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The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trialNARA Subscribed
Psychopharmacology · 2026 · Vol. 243 · Issue 4 · Springer
Peter C. T. Hawkins; Adam J. Schwarz; James M. Stone; Fiona Pepper; James Gilleen; Sam Gijsen; Ndabezinhle Mazibuko; Dimitrios Arkilo; Wei Yin; Jingtao Wu; Polyna Khudyakov; Rhett Behrje; Laura Rosen; Joel Posener; Mitul A. Mehta; Antonio Laurenza
The negative and cognitive symptoms of schizophrenia are predictive of quality of life and functional recovery, but there are no approved drug options that target these symptoms directly. TAK-041 (also known as NBI-1065846) is a selective and potent small-molecule agonist of GPR139, an orphan G-protein-coupled receptor, which has been shown to reverse deficits related to negative and cognitive symptoms in animal models. In thi...
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