While acute inflammation is an essential physical response to harmful external influences, the transition to chronic inflammation is problematic and associated with the development and worsening of many deadly diseases. Until now, established pharmaceutical agents have had many side effects when used for long periods. In this study, a possible anti-inflammatory effect of the sesquiterpene α-humulene on lipopolysaccharide (LPS)...

Objectives The objective of the study was to develop a strategy for the identification of new vitamin B 12 -producing species and to characterize their production capability using a fast and sensitive LC–MS/MS method developed in this study. Results Searching for homologues of the bluB / cobT2 fusion gene known to be responsible for the production of the active vitamin B 12 form in P. freudenreichii was shown to be a successfu...

Several bacterial species are known for their ability to synthesize vitamin B 12 but biotechnological vitamin B 12 production today is restricted to Pseudomonas denitrificans and Propionibacterium freudenreichii . Nevertheless, the rising popularity of veganism leads to a growing demand for vitamin B 12 and thereby interest in alternative strains which can be used as efficient vitamin B 12 sources. In this work, we demonstrate...

Process intensification aims at enabling bridging the gap between fundamental research such as identification of new catalysts and reactions and their implementation in industrial environments. Especially the field of biocatalysis has seen some tremendous improvements and the development of new tools and approaches to bridge this gap. In this contribution we highlight some recent developments as selected case studies.

In chemical process engineering, process intensification (PI) has proven itself as a method that resulted very often in processes with an at least doubled process performance. In recent years, the PI techniques have found more and more applications in biotechnology. Exemplary continuous processes, single-use reactors, electrobiotechnology and hybrid techniques are discussed here.