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The inverse autotransporters of Yersinia ruckeri , YrInv and YrIlm , contribute to biofilm formation and virulenceNARA Subscribed
Summary Yersinia ruckeri causes enteric redmouth disease (ERM) that mainly affects salmonid fishes and leads to significant economic losses in the aquaculture industry. An increasing number of outbreaks and the lack of effective vaccines against some serotypes necessitates novel measures to control ERM. Importantly, Y. ruckeri survives in the environment for long periods, presumably by forming biofilms. How the pathogen forms...
Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targetsNARA Subscribed
The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular env...
Distinct mechanisms contribute to immunity in the lantibiotic NAI ‐107 producer strain M icrobispora ATCC PTA ‐5024NARA Subscribed
The investigation of self‐resistance in antibiotic producers is important to understand the emergence of antibiotic resistance in pathogens and to improve antibiotic production. Lantibiotics are ribosomally synthesized antibiotics that mostly target peptidoglycan biosynthesis. The actinomycete M icrobispora ATCC PTA ‐5024 produces the lantibiotic NAI ‐107, which interferes with peptidoglycan biosynthesis by binding bactoprenol...
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