Nanostraw arrays represent a novel and promising approach for the controlled delivery of substances into cells characterized by very little cellular activation or damage. Herein, we describe a sensitive strategy to establish intracellular contact with human macrophage-like differentiated THP-1 cells. Macrophages must function under stressful in-vivo conditions in oxygen-deprived tissues with inflammation. THP-1 cells stayed he...

In order to achieve the commonly agreed emission reduction target, the European Commission called upon the member states to submit National Energy and Climate Plans to ensure increased transparency for the respective national targets and strategies. An analysis of these plans shows that some member states have declared ambitious emission reductions targets, as well as technology-specific phaseout policies in the power sector....

The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, cl...

Decompression illness (DCI) is a complex clinical syndrome caused by supersaturation of respiratory gases in blood and tissues after abrupt reduction in ambient pressure. The resulting formation of gas bubbles combined with pulmonary barotrauma leads to venous and arterial gas embolism. Severity of DCI depends on the degree of direct tissue damage caused by growing bubbles or indirect cell injury by impaired oxygen transport,...