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This study sought to evaluate the characteristics of clinical-pharmacological (CP) medication reviews conducted by the Institute for Clinical Pharmacology of Hannover Medical School for older, multimorbid, polymedicated insurants of the German statutory health insurance fund Kaufmännische Krankenkasse (KKH). Special emphasis was put on potential sex-specific differences between female and male insurants, prescriptions of poten...
Rechtsprechung zu toxikologischen SchwellenwertenNARA Subscribed
Zusammenfassung Toxikologische Schwellenwerte wie die duldbare tägliche Aufnahmemenge (Acceptable Daily Intake, ADI), die akute Referenzdosis (ARfD) und die niedrigste Dosis mit beobachteter schädlicher Wirkung (Lowest Observed Adverse Effect Level, LOAEL) sind entscheidend für die Bewertung der Sicherheit von Lebensmitteln. Sie berücksichtigen potenzielle Risiken durch Kurz- und Langzeitexposition gegenüber bestimmten Inhalts...
Freshwater organisms are suitable models to study the fate of environmental pollutants. Due to their versatile and everyday use, many environmental pollutants such as triclocarban (TCC) or multi-walled carbon nanotubes (MWCNTs) enter environmental compartments very easily. TCC is known as a disinfectant and is declared as a highly aquatic toxicant. Multi-walled carbon nanotubes are used, e.g., in the automotive industry to imp...
Terrestrial ecosystems affect climate by reflecting solar irradiation, evaporative cooling, and carbon sequestration. Yet very little is known about how plant traits affect climate regulation processes (CRPs) in different habitat types. Here, we used linear and random forest models to relate the community‐weighted mean and variance values of 19 plant traits (summarized into eight trait axes) to the climate‐adjusted proportion...
Ecosystem functions and services are severely threatened by unprecedented global loss in biodiversity. To counteract these trends, it is essential to develop systems to monitor changes in biodiversity for planning, evaluating, and implementing conservation and mitigation actions. However, the implementation of monitoring systems suffers from a trade‐off between grain (i.e., the level of detail), extent (i.e., the number of stu...
Zusammenfassung Das Vorsorgeprinzip ist in der Rechtsprechung und Gesetzgebung der Europäischen Union (EU) fest verankert. Im Lebensmittelrecht wurde das Vorsorgeprinzip in Art. 7 der Lebensmittel-Basisverordnung (EG) Nr. 178/2002 (BasisVO) etabliert. Dennoch findet das Vorsorgeprinzip sowohl in der Überwachungspraxis als auch in der nationalen Rechtsprechung nicht die angemessene Beachtung. Neben der historischen Entwicklung...
What do older patients know about their medication? A cross-sectional, interview-based pilot studyNARA Subscribed
Purpose This study sought to analyze the medication knowledge and awareness of medication adjustment options during intercurrent illness (sick day rules) of patients ≥ 70 years treated at a hospital for geriatric medicine in northern Germany. Methods The study was designed as a cross-sectional, interview-based pilot study, was approved by the Ethics Committee of Hannover Medical School (No. 10274_BO_K_2022; date of approval: 1...
The assessment of foods containing botanicals above toxicological thresholds poses challenges, as administrative court decisions have set high barriers for the application of Art. 14 para. 2a or 2b of the General Food Law Regulation (EC) No 178/2002. If the application of Art. 14 para. 2b of the General Regulation is restricted by a narrow interpretation of para. 5 to contamination, putrefaction, spoilage or decomposition, a r...
Multi-year, post-harvesting impact assessment in a neotropical secondary Atlantic ForestNARA Subscribed
Subject to overexploitation in the past centuries, the Atlantic Forest is subject to very rigorous protection rules. However, the law is a controversial issue since landowners are not compensated for the limited choice of land use possibilities. We believe that, alternatively to a general timber harvest ban, sustainable forest management of the Atlantic Forest has the potential to generate income for the landowners while susta...
Trafficability Prediction Using Depth-to-Water Maps: the Status of Application in Northern and Central European ForestryNARA Subscribed
Purpose of Review Mechanized logging operations with ground-based equipment commonly represent European production forestry but are well-known to potentially cause soil impacts through various forms of soil disturbances, especially on wet soils with low bearing capacity. In times of changing climate, with shorter periods of frozen soils, heavy rain fall events in spring and autumn and frequent needs for salvage logging, forest...
sPlotOpen – An environmentally balanced, open‐access, global dataset of vegetation plotsNARA Subscribed
Motivation Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co‐occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots...
The inverse autotransporters of Yersinia ruckeri , YrInv and YrIlm , contribute to biofilm formation and virulenceNARA Subscribed
Summary Yersinia ruckeri causes enteric redmouth disease (ERM) that mainly affects salmonid fishes and leads to significant economic losses in the aquaculture industry. An increasing number of outbreaks and the lack of effective vaccines against some serotypes necessitates novel measures to control ERM. Importantly, Y. ruckeri survives in the environment for long periods, presumably by forming biofilms. How the pathogen forms...