Introduction Adolescents and Young Adults (AYAs) aged 15–39 represent a unique oncology demographic due to their distinct developmental needs. However, there is limited data on cancer burden and care disparities among the Indian AYAs. This study examines the burden, pattern, and disparities among AYAs in Varanasi, Uttar Pradesh. Methods This study collected data from Varanasi's population-based cancer registry (PBCR) between 2...

Summary C3G (RAPGEF1), engaged in multiple signaling pathways, is essential for the early development of the mouse. In this study, we have examined its role in mouse embryonic stem cell self-renewal and differentiation. C3G null cells generated by CRISPR mediated knock-in of a targeting vector exhibited enhanced clonogenicity and long-term self-renewal. They did not differentiate in response to LIF withdrawal when compared to...