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Springer Nature1
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Human Genetics1
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20221
Dmitrii Nechaev results 1 · Newest (Page 1/1, per page 25)
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Embeddings from protein language models predict conservation and variant effectsNARA Subscribed
Human Genetics · 2022 · Vol. 141 · Issue 10 · Springer
Céline Marquet; Michael Heinzinger; Tobias Olenyi; Christian Dallago; Kyra Erckert; Michael Bernhofer; Dmitrii Nechaev; Burkhard Rost
The emergence of SARS-CoV-2 variants stressed the demand for tools allowing to interpret the effect of single amino acid variants (SAVs) on protein function. While Deep Mutational Scanning (DMS) sets continue to expand our understanding of the mutational landscape of single proteins, the results continue to challenge analyses. Protein Language Models (pLMs) use the latest deep learning (DL) algorithms to leverage growing datab...
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