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Polycyclic aromatic hydrocarbons (PAHs) in marine sediments pose potential ecological risks, and systematic investigations of their distribution, sources, and risks are critical for coastal environmental management.This study systematically investigates the distribution, source apportionment, and ecological risks of 16 polycyclic aromatic hydrocarbons (PAHs) in surface sediments of the western Beibu Gulf, Guangxi. The total PA...
Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patientsNARA Subscribed
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible dosing regimen optimization. Subject and methods In this study, we used a population-based meta-analysis approach to develop a population PK model to characterize the CQ PK in COVID-...