Drug-induced liver injury remains a major obstacle in pharmaceutical development and a leading cause of acute liver failure, underscoring the need for predictive and human-relevant in vitro models. Acetaminophen, a widely used analgesic with well-characterized dose-dependent hepatotoxicity, serves as a benchmark compound for evaluating liver toxicity mechanisms. Here, we applied single cell RNA sequencing to characterize cellu...

Plant microbiomes are diverse communities of many microbial species. Growing evidence suggests that a complex network of interactions between members of the microbiome is necessary to maintain the health of host plants. Overall microbiome impacts can be difficult to predict and there is still much unknown about how taxonomic diversity links to function. All research on such dynamics so far has been limited to vascular plants,...

The liver plays an important role in xenobiotic metabolism and represents a primary target for toxic substances. Many different in vitro cell models have been developed in the past decades. In this study, we used RNA-sequencing (RNA-Seq) to analyze the following human in vitro liver cell models in comparison to human liver tissue: cancer-derived cell lines (HepG2, HepaRG 3D), induced pluripotent stem cell-derived hepatocyte-li...