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NARA Subscribed1
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Springer Nature1
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Human Genetics1
Publication Year
20241
Dylan Carter-Cusack results 1 · Newest (Page 1/1, per page 25)
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The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel diseaseNARA Subscribed
Human Genetics · 2024 · Vol. 143 · Issue 3 · Springer
Claire L. O’Brien; Kim M. Summers; Natalia M. Martin; Dylan Carter-Cusack; Yuanhao Yang; Rasel Barua; Ojas V. A. Dixit; David A. Hume; Paul Pavli
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of genome-wide association studies (GWAS) indicates that dysregulation of macrophage differentiation and response to microorganisms contributes to susceptibility to chronic inflammatory bowel disease (IBD). Here, we analyzed transcriptomic variation in monocyt...
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