E. D. Benjamin results 232
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Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Eukaryotic Biodiversity and Ecological Networks From the Surface to the Mesopelagic in the Northwest Atlantic Slope WaterNARA Subscribed
The diversity and interactions among mesopelagic organisms are difficult to study and, as a result, are insufficiently unaccounted for in food web and biogeochemical models. This knowledge gap hinders our ability to model and forecast ecosystem function and formulate effective policies for conservation and management in the face of growing interest in exploiting midwater living resources. We used multi‐marker metabarcoding of...
Evaluation of siRNA-mediated knockdown of heat shock protein 16.2 in adult Acropora cervicornisOA Marine
Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult cor...
Shortleaf Pine (Pinus echinata): Management Challenges, Knowledge Gaps, and Opportunities for an Unsung SpeciesNARA Subscribed
Shortleaf pine has the broadest range of the southern pine species, occurring in 22 states and extending north into New Jersey, Pennsylvania, and New York (Staten Island). Shortleaf pine has been understudied compared to loblolly pine and longleaf pine, typically favored for timber production and conservation value, respectively. The extensive range of shortleaf pine contributes to a high degree of variability within and among...
Methane is a potent greenhouse gas, which traps significantly more heat than carbon dioxide over short timescales, but remains underrepresented in models used for projecting future climate scenarios, particularly in permafrost landscapes. Understanding methane dynamics in northern wetlands is critical for improving projections of high‐latitude carbon feedbacks to the global climate system. To address this, we integrated ecolog...
During the 4th Global Coral Bleaching Event (GCBE4; January 2023–September 2025), an extreme marine heatwave occurred on the Bocas del Toro Reef Complex (BTRC) in Panama. We characterized how this heatwave impacted the health and holobiont communities of the stress‐tolerant coral Siderastrea siderea at four sites across the BTRC. Tagged colonies at each site ( N = 30–53 colonies per site) were visited before, during, and after...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Background Controlled laboratory studies have demonstrated that breaking up sitting can reduce postprandial glucose in South Asian adults. This study examined the effects of substituting sitting with standing and walking on interstitial glucose in South Asian individuals under free-living conditions. Methods South Asian adults ( n = 14 [50% male]; body mass index 26.5 ± 0.8 kg·m −2 ) aged 41 ± 3 years completed two, 4-day regi...
Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast CancerNARA Subscribed
Purpose Tumor-associated macrophages (TAMs) are the most abundant immune cells in primary solid tumors, including breast cancer, and typically exhibit an M2-like, immunosuppressive phenotype that promotes tumor growth. Given that TAMs can be repolarized through cytokine signaling, we propose a localized cytokine delivery depot using an injectable alginate cryogel to reprogram TAMs and create an inflammatory, anti-tumor TME. Me...
The Amundsen Sea polynya hosts intense sea ice formation, but, due to the presence of relatively warm and salty modified Circumpolar Deep Water, the cold, brine-enriched water is not typically dense enough to sink to the deep ocean. A hydrographic survey of the Dotson Ice Shelf region in the Amundsen Sea using two ocean gliders identified and characterised subsurface lenses containing water with temperatures less than −1.70 °C...
Geographic variation in stable isotope ratios of subtropical American eel (Anguilla rostrata)NARA Subscribed
American eel ( Anguilla rostrata ) life history strategies and food web interactions are highly variable in temperate climates but not well understood in sub-tropical hydrologic systems. Intraspecific variability in isotopic niche breadth and overlap can have major implications for species of conservation concern by revealing dietary plasticity of populations across varied habitats. Muscle tissue stable isotope ratios of carbo...