E. Gabriel results 503
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Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesityNARA Subscribed
Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...
Gonatobotryum is an anamorphic fungus reported mainly as a saprophyte, parasite, or endophyte. The genus has traditionally been identified based on morphological features, with its phylogenetic placement remaining uncertain due to the lack of molecular data. During the analysis of fungi obtained from mangrove sediments in Brazil, nine isolates were morphologically identified as Gonatobotryum and subsequently analysed using the...
This study evaluated the effects of providing 3–15 kg of a soluble and biodegradable biopolymer-based enrichment material (blend of biodegradable polymers and natural fibers) to prepartum sows housed in farrowing crates. Fifteen sows were blocked by body weight and backfat thickness and assigned to three treatments: no enrichment material (CONT), 3 kg of enrichment material (BN3), or 15 kg of enrichment material with added nut...
Concomitant circulation of lentiviruses and Mycoplasma spp. in dairy goats: a clinical and multi-sample diagnostic approachNARA Subscribed
The health of dairy goat herds may be compromised by infections caused by small ruminant lentiviruses (SRLV) and Mycoplasma agalactiae , particularly under coinfection conditions. This study investigated a dairy goat herd composed of 38 animals with a history of joint enlargement and reduced milk production in Northeastern Brazil. Clinical, serological, molecular, and phylogenetic analyses were performed using blood, milk, syn...
The feeding behavior of the amphicyonid Magericyon anceps from the Batallones-1 fossil site has been investigated so far based on comparative anatomy, which provided a functional hypothesis of this carnivoran as being a capable hunter rather than a scavenger. In this work, we study the feeding behavior of M. anceps under a biomechanical approach using the virtual paleontology toolbox. Our results suggest that M. anceps was wel...
The shallow Baltic Sea is a vital waterway with dense shipping traffic, requiring accurate and reliable nautical charts for safe navigation. Until recently, different realisations of the mean sea level were used in the paper charts of each country, sometimes even between harbours. This created obstacles for the digitalisation of ship navigation, including electronic nautical charts combined with satellite-based positioning. To...
Development of citrinin-loaded liposomes and in vitro toxicogenetic evaluation on breast cellsNARA Subscribed
This study aimed to synthesize a liposomal nanoformulation containing citrinin (LP-CIT) to improve its availability and to evaluate its toxicogenomic profile, focusing on cytotoxic and genotoxic effects in breast cancer (MDA-MB-231) and non-tumorigenic mammary epithelial (MCF-10A) cell lines. The formulation was characterized by macroscopic appearance, pH, particle size, polydispersity index (PDI), zeta potential, encapsulatio...
Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...
Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
Ageing in Honeybees: Telomere Length Is Driven by Climate and Resource Availability Rather Than Urbanisation or PollutionNARA Subscribed
Understanding how biodiversity responds to human‐caused environmental change represents a major scientific challenge. Among the biological processes underlying these responses, ageing plays a critical role by shaping individual life histories and, ultimately, demographic dynamics. Telomeres, the repetitive nucleotide sequences at the ends of linear chromosomes, are widely used biomarkers of ageing, as their length can be shape...