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In 2023, more than half of olive harvests ( Olea europaea ) across Spain, Greece, and Türkiye were lost to drought. The same year late freeze destroyed 90% of the peach crop ( Prunus persica ) on the Georgia Piedmont and the apple crop ( Malus domestica ) in central New York, Vermont, and southern Quebec. Climate extremes now rank with the costliest threats to agriculture, but their role in forest recovery from diebacks that a...
Insights into the evolution of a post-failure rock slopeNARA Subscribed
Rock slope failure is commonly regarded as the most significant phase in the evolution of an unstable rock slope. However, many rock slopes do not fail in a single event but rather in several individual ones. Such polyphase rock slope failures impose a challenge, as their post-failure evolution is hard to predict, and the time interval between the failure events, their magnitude, and running-out distance can differ significant...
Development and in vitro evaluation of a lignin-PLGA nanocarrier for florfenicol deliveryNARA Subscribed
Florfenicol (FF) is a widely used antimicrobial in veterinary medicine because of its broad antimicrobial activity, although it has certain limitations and raises concerns about the development of antimicrobial resistance genes. These limitations highlight the need to explore novel drug with controlled release systems to enhance the therapeutic efficacy of FF, while minimizing the potential for resistance development. This stu...
The Relationship Between Maturation Size and Maximum Tree Size From Tropical to Boreal ClimatesNARA Subscribed
The fundamental trade‐off between current and future reproduction has long been considered to result in a tendency for species that can grow large to begin reproduction at a larger size. Due to the prolonged time required to reach maturity, estimates of tree maturation size remain very rare and we lack a global view on the generality and the shape of this trade‐off. Using seed production from five continents, we estimate tree...
Terrestrial ecosystems affect climate by reflecting solar irradiation, evaporative cooling, and carbon sequestration. Yet very little is known about how plant traits affect climate regulation processes (CRPs) in different habitat types. Here, we used linear and random forest models to relate the community‐weighted mean and variance values of 19 plant traits (summarized into eight trait axes) to the climate‐adjusted proportion...
Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteersNARA Subscribed
Purpose A population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing regimens were evaluated in terms of the probability of target attainment for Escherichia coli using both plasma and urinary pharmacokinetic/pharmacodynamic targets. Methods Eight healthy men received fosfomycin as both intermittent 8 g q8h and continuous infusion 1 g/h with a loadi...