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NARA Subscribed2
Publisher
Springer Nature2
Journal
✓Purinergic Signalling2
Publication Year
20242
El-Sayed Akool results 2 · Newest (Page 1/1, per page 25)
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Journal: Purinergic Signalling ×Author: El-Sayed Akool ×Clear All Filters
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Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuRNARA Subscribed
Purinergic Signalling · 2024 · Vol. 20 · Issue 6 · Springer
Abdel-Aziz S. Shatat; Elsayed M. Mahgoup; Mohammed H. Rashed; Ibrahim G. Saleh; El-Sayed Akool
One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC proliferation and progression. Human antigen R (HuR) is becoming more and more understood to be essential for the expression of genes linked to cancer. The current study demonstrates that ATP can mediate CRC (Caco-2 cells) progression via induction of HuR n...
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P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathwayNARA Subscribed
Purinergic Signalling · 2024 · Vol. 20 · Issue 4 · Springer
Fatma Mounieb; Somaia A Abdel-Sattar; Amany Balah; El-Sayed Akool
This study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via the P2 X 7 receptor to activate the renal fibrotic processes in rats. The present study demonstrates that administration of ATP rapidly activated transforming growth factor-β (TGF-β) to induce phosphorylation of Smad-2/3. Renal connective tissue growth factor (CTGF) and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA...
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