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NARA Subscribed2
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Springer Nature2
Journal
Inflammopharmacology1
Naunyn-Schmiedeberg's Archives of Pharmacology1
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20261
20251
El-Sayed E. El-Awady results 2 · Newest (Page 1/1, per page 25)
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Author: El-Sayed E. El-Awady ×Clear All Filters
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Neuroprotection by canagliflozin in a Huntington’s disease model: role of HIF-1α and PI3K/AKT signalingNARA Subscribed
Naunyn-Schmiedeberg's Archives of Pharmacology · 2026 · Vol. 399 · Issue 6 · Springer
Ali M. Elgindy; El-Sayed E. El-Awady; Norhan M. El-Sayed; Naglaa F. El-Orabi; Ahmed M. Atwa
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and metabolic dysfunction, largely driven by mitochondrial impairment and defective energy metabolism. Altered signaling through hypoxia-inducible factor-1α (HIF-1α) and PI3K/AKT cascades contributes to neuronal vulnerability. Canagliflozin (Cana), a sodium–glucose cotransporter-2 inhibitor, has shown cognitive benefits in...
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Neuroprotective effects of candesartan in 3-nitropropionic acid-induced Huntington’s disease: modulation of angiotensin and CREB/BDNF/PGC1-α signalingNARA Subscribed
Inflammopharmacology · 2025 · Vol. 33 · Issue 10 · Springer
Ali M. Elgindy; Ahmed M. Atwa; El-Sayed E. El-Awady; Norhan M. El-Sayed; Naglaa F. El-Orabi
Renin–Angiotensin System has been implicated in neurodegenerative diseases such as Huntington’s (HD). It is made up of two axes: one is the Angiotensin II Type 1 receptor (AT1R) or Angiotensin II Type 2 receptor (AT2R), while the other is angiotensin-(1-7) [Ang-(1-7)], and Mas receptor; the latter has reported developing a neuroprotective effect; oppositely, AT1R activation has been linked to neurodegenerative diseases. This s...
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