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The effect of piperine on midazolam plasma concentration in healthy volunteers, a research on the CYP3A-involving metabolismNARA Subscribed
Some studies showed that piperine (the alkaloid of piper nigrum ) can change the activities of microsomal enzymes. Midazolam concentration is applied as a probe to determine the CYP3A enzyme activity. This study was done to determine piperine pretreatment role on midazolam plasma concentration. Twenty healthy volunteers (14 men and 6 women) received oral dose of piperine (15 mg) or placebo for three days as pretreatment and mi...
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