Ongoing concerns about the impact of climate change on Australia’s oceans has driven a request from fisheries managers for improved science communication to the seafood sector. Despite these concerns, translating climate science into management and industry action at regional and sectoral scales remains a challenge. We developed a reporting structure for communicating climate and ecosystem status to fisheries management, indus...

Background Triple-negative breast cancer (TNBC) is an aggressive subtype with high chemoresistance and poor survival rates. While mitochondrial dynamics, fission and fusion, are implicated in chemoresistance, their precise roles remain largely unexplored. This study investigates how cytoplasmic phosphatases SHP-1 and SHP-2 regulate chemotherapeutic response in TNBC cells with altered mitochondrial dynamics. Methods We utilized...

Glaucoma is a complex neurodegenerative disease with multiple subtypes, yet all are characterized by the progressive dysfunction and loss of retinal ganglion cells (RGCs), which ultimately results in vision impairment and blindness. Elevated intraocular pressure (IOP) is a major risk factor for glaucoma; however, it is neither necessary nor sufficient for glaucomatous neurodegeneration, as patients can exhibit high IOP without...

We analyzed the International Mouse Phenotyping Consortium (IMPC) release 19 set of 8,539 phenotyped whole-gene knockouts to identify 204 genes that alter vertebral anatomy and development. These genes are broadly grouped into six categories based on their phenotype: “vertebral number” (22 genes); “vertebral processes” (35 genes); “spine shape” (16 genes); “tail morphology” (73 genes); “vertebral form” (62 genes); and “somitog...

Telomere shortening is a key marker of cellular aging and linked to pathologies such as liver disease. Oxidative stress and inflammation (hallmarks of obesity) contribute to telomere shortening, while omega-3 (DHA) and exercise may counteract these effects by enhancing cellular homeostasis. This study aims to analyze the influence of DHA supplementation and/or exercise over one year on liver telomere length in obese aged mice....

While falling costs have expanded access to genomic sequencing, clinical utility is frequently hindered by the challenge of interpreting complex genetic data. Variant analysis for rare disease patients especially requires significant time and expertise, creating a bottleneck that delays diagnostics. Although advances in genetic variant classification have improved diagnostic precision, they have also increased the identificati...

Social communication (SC) relies on the integration of linguistic processing, pragmatic inference, and theory of mind (ToM), yet its neural architecture remains insufficiently characterized. We propose and empirically test a unified SC network by integrating information neural graph theory metrics, multi-domain cognitive modeling, and autistic traits. Forty-five neurotypical adults completed a cognitive battery assessing langu...