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NARA Subscribed1
Publisher
Springer Nature1
Journal
Naunyn-Schmiedeberg's Archives of Pharmacology1
Publication Year
20261
Elizabeth Cheesman results 1 · Newest (Page 1/1, per page 25)
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Author: Elizabeth Cheesman ×Clear All Filters
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β1- and β2-adrenergic receptor mediated spontaneous contractions and ryanodine receptor channel opening in human failing heartNARA Subscribed
Naunyn-Schmiedeberg's Archives of Pharmacology · 2026 · Springer
Weilan Mo; Nicole A. Beard; Katherine T. Gillette-Browne; Karen Hay; Elizabeth Cheesman; Alexander Dashwood; Melanie Spratt; Annalese B. Semmler; Yee Weng Wong; Haris Haqqani; Derek R. Laver; Torsten Christ; Kafa Walweel; Peter Molenaar
In heart failure, β-adrenergic receptor (β-AR)-Gsα-cAMP-protein kinase A (PKA) signalling predisposes to delayed-afterdepolarisation-mediated arrhythmias. Phosphodiesterases (PDEs) hydrolyse cAMP, and PDE3 restrains β 1 -AR, β 2 -AR-mediated inotropic responses in failing hearts from β-blocker-treated patients. Whether these receptors provoke arrhythmias through ryanodine receptor (RyR2) dysregulation, and how PDE activity and...
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