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Building climate-smart fisheries in Australia: insights from climate and ecosystem status reportsNARA Subscribed
Ongoing concerns about the impact of climate change on Australia’s oceans has driven a request from fisheries managers for improved science communication to the seafood sector. Despite these concerns, translating climate science into management and industry action at regional and sectoral scales remains a challenge. We developed a reporting structure for communicating climate and ecosystem status to fisheries management, indus...
Although plasma pTau181 has been shown to accurately discriminate patients with Alzheimer’s disease from healthy older adults, there are few studies of plasma biomarkers among middle-aged populations. Given the potential utility of plasma AD biomarkers such as pTau181 in screening for disease risk, examining pTau181 in a middle-aged cohort without AD is important for future implementation. The objectives of this study were to...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Environmental factors shape the distributions of organisms and their underlying patterns of genetic variation. When climate changes rapidly, organisms that are adapted to current environments may become maladapted to future climates. Long‐lived tree species are especially susceptible to climate maladaptation due to their sessile nature and long generation times. Understanding how foundational tree species will respond to futur...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Conservation genomics of the imperiled Leon springs pupfish, Cyprinodon bovinus, across temporal and spatial scalesNARA Subscribed
The Leon Springs pupfish, Cyprinodon bovinus , is federally listed as endangered and currently confined to spring-fed pools on the Diamond Y Spring Preserve in Pecos County, Texas, USA. A refuge population is maintained by U.S. Fish and Wildlife Service in Dexter, New Mexico, USA because of ongoing threats from hybridization with the introduced congener, the sheepshead minnow, C. variegatus. To inform continued conservation an...
Purpose Breast cancer etiology is multifactorial with African American women experiencing a significant health disparity in clinical presentation and outcomes. The selenium-containing protein SELENOF has been implicated in breast carcinogenesis by cell culture and animal studies. SELENOF translation is highly regulated in part by the RNA helicase eIF4a3, which binds to the key regulatory regions in the SELENOF mRNA and suppres...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaineNARA Subscribed
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places a significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer a promising alternative for delivering sustained drug doses in the treatment of chronic conditions. This study introduces a novel long-acting subcutaneous implant for dual-d...
Evaluating Seasonal vs. Spatial Extrapolation for Cetacean Distribution Models in the California CurrentNARA Subscribed
Species distribution models (SDMs) have been developed for multiple cetacean species within the California Current Ecosystem (CCE) from shipboard survey data collected by the Southwest Fisheries Science Center (SWFSC) in summer and fall, thus limiting the ability to inform management decisions in cool seasons when abundance and distribution patterns are substantially different. Winter and spring SDMs have been developed for a...
Arthropod declines have been reported widely; however, a lack of comprehensive data has hindered our ability to assess their large‐scale generality and drivers. Here, we used a novel and freely available dataset—atmospheric scans from a network of meteorological radars—to quantify aerial abundance of both diurnal and nocturnal arthropods across the United Kingdom, spanning different geographic regions and land cover types. Bas...