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Mineral Stabilization Slows Losses of Peatland Carbon Following Long‐Term Drainage for AgricultureNARA Subscribed
Cultivated peatlands are a major CO 2 emission source, but the processes that regulate the decomposition of drained peat are debated, especially as drained peat becomes increasingly shallow. Many cultivated peatlands are underlain by a mineral soil layer. Surface subsidence, oxidation and tillage reduce the peat thickness, which intermixes peat with minerals as peat is lost. A key question is whether this mixing can reduce emi...
Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humansNARA Subscribed
Biomarkers of aging, particularly DNA methylation-based clocks, have shown promise as tools to assess whether interventions may impact the rate of biological aging. Among possible interventions physical exercise has shown protective effects against many age-associated diseases, while time-restricted feeding (TRF) has shown metabolic benefits in preclinical models. The combined effect of exercise and TRF on aging biomarkers rem...
Mite domatia — small structures on plant leaves that house mutualistic mites — are widespread across plants yet remain relatively understudied. Here we investigate the chemistry and micromorphology of mite domatia across sympatric species of broadleaf deciduous woody species that have convergently evolved tuft-form mite domatia. Specifically, we test whether domatia display similar micromorphological and chemical properties us...
The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...
Concatenation, Conflict, and Complexity: Genealogical Heterogeneity Mimics Substitutional Heterogeneity for Nucleotide Model SelectionNARA Subscribed
Phylogenetic conflict—particularly hidden gene-tree discordance generated by incomplete lineage sorting (ILS)—is pervasive in multilocus and phylogenomic datasets, yet its consequences for nucleotide substitution model selection remain poorly understood. Modern molecular studies increasingly collect and concatenate large sets of independent loci sampled across distant and often poorly characterized regions of the genome, creat...
Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshopNARA Subscribed
Artificial Intelligence (AI) is increasingly influencing chemical risk assessment, enabling faster, more comprehensive, and potentially more ethical assessments. The application of AI in chemical risk assessment refers to both generative and predictive algorithms encompassing machine learning, to analyse complex chemical, biological, and environmental data and provide insights into adverse effect potential for humans and ecosy...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The red seaweed Asparagopsis taxiformis can reduce methane emissions in livestock by over 90%, but its mariculture remains in its infancy and biomass for research and commercial use relies partly on wild populations. Knowledge on the impacts of harvesting A. taxiformis is lacking, emphasising the need for ecological research to guide the development of its sustainable harvesting. This study examined the regrowth potential of A...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed