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Pharmaceutical Research · 2024 · Vol. 41 · Issue 9 · Springer
Objective Pancreatic ductal adenocarcinoma (PDAC) is characterized by desmoplasia due to increased deposition of extracellular matrix (ECM) proteins. This work investigates the efficacy of targeted ECO/miR-200c nanoparticles (ELNP) on ECM remodeling in PDAC and tumor proliferation with MR molecular imaging (MRMI) with MT218 in immunocompetent mouse models. Methods The miR-200c mediated regulation of EMT markers was measured in...