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The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
NCBI Orthologs: Public Resource and Scalable Method for Computing High-Precision Orthologs Across Eukaryotic GenomesNARA Subscribed
Orthologs are fundamental for enabling comparative genomics analyses that further our understanding of eukaryotic biology. The unprecedented increase in the availability of high-quality eukaryotic genomes necessitates scalable and accurate methods for orthology inference. The National Center for Biotechnology Information (NCBI) developed “NCBI Orthologs”, a resource and a computational pipeline designed to meet this challenge...
Unraveling intragenomic polymorphisms in the high-quality genome of Hypoxylaceae: a comprehensive study of the rDNA cistronNARA Subscribed
Sequencing ribosomal DNA loci, such as ITS and LSU, are among the first steps to characterize and identify newly isolated fungal strains. Substantial doubt has recently been raised concerning the unequivocal suitability of using this sequence information for inferring inter- and intraspecific relationships, as especially the ITS locus was repeatedly shown to harbor high intragenomic plasticity. The evolutionary mechanisms lead...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Integrating larval connectivity into the marine conservation decision‐making process across spatial scalesNARA Subscribed
Larval dispersal connectivity is typically integrated into spatial conservation decisions at regional or national scales, but implementing agencies struggle with translating these methods to local scales. We used larval dispersal connectivity at regional (hundreds of kilometers) and local (tens of kilometers) scales to aid in design of networks of no‐take reserves in Southeast Sulawesi, Indonesia. We used Marxan with Connectiv...
Comparing spatial conservation prioritization methods with site‐ versus spatial dependency‐based connectivityNARA Subscribed
Larval dispersal is an important component of marine reserve networks. Two conceptually different approaches to incorporate dispersal connectivity into spatial planning of these networks exist, and it is an open question as to when either is most appropriate. Candidate reserve sites can be selected individually based on local properties of connectivity or on a spatial dependency‐based approach of selecting clusters of strongly...
Intragenomic polymorphisms in the ITS region of high-quality genomes of the Hypoxylaceae (Xylariales, Ascomycota)NARA Subscribed
The internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA) has been established (and is generally accepted) as a primary “universal” genetic barcode for fungi for many years, but the actual value for taxonomy has been heavily disputed among mycologists. Recently, twelve draft genome sequences, mainly derived from type species of the family Hypoxylaceae (Xylariales, Ascomycota) and the ex-epitype strain of Xylaria...
The Australian National Rabbit Database: 50 yr of population monitoring of an invasive speciesNARA Subscribed
With ongoing introductions into Australia since the 1700s, the European rabbit ( Oryctolagus cuniculus ) has become one of the most widely distributed and abundant vertebrate pests, adversely impacting Australia's biodiversity and agroeconomy. To understand the population and range dynamics of the species and its impacts better, occurrence and abundance data have been collected by researchers and citizens from sites covering a...
Summary Enfumafungin is a glycosylated fernene‐type triterpenoid produced by the fungus Hormonema carpetanum . Its potent antifungal activity, mediated by its interaction with β ‐1,3‐glucan synthase and the fungal cell wall, has led to its development into the semi‐synthetic clinical candidate, ibrexafungerp (=SCY‐078). We report on the preliminary identification of the enfumafungin biosynthetic gene cluster (BGC) based on gen...
Natural hazards in Australia: sea level and coastal extremesNARA Subscribed
Mouse genome annotation by the RefSeq projectNARA Subscribed
Complete and accurate annotation of the mouse genome is critical to the advancement of research conducted on this important model organism. The National Center for Biotechnology Information (NCBI) develops and maintains many useful resources to assist the mouse research community. In particular, the reference sequence (RefSeq) database provides high-quality annotation of multiple mouse genome assemblies using a combinatorial a...