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Metatranscriptomic analysis of public RNA-seq data from Dendrobium catenatum , an economically and culturally important orchid, revealed a highly diverse virome. Sixteen exogenous viral species were detected, representing seven families of RNA viruses, including positive-sense ssRNA viruses ( Botourmiaviridae , Mitoviridae , Narnaviridae , Endornaviridae , and Fusariviridae ) and double-stranded RNA viruses ( Phlegviridae and...
Chikungunya virus (CHIKV) is an arthropod-borne virus responsible for an acute febrile illness characterized by severe polyarthralgia, predominantly affecting peripheral joints. In a substantial proportion of patients, these symptoms may progress to chronic manifestations that significantly impair quality of life. Animal models are therefore critical for the development of effective therapeutic and preventive strategies, inclu...
Mining viruses in public databases unveils the diversity within the Deltaflexiviridae familyNARA Subscribed
Cloud computing platforms aided the scalability and applicability of viral mining in genomic databases. The Serratus project reported SRA accessions that may contain viral sequences. This study analyzed SRA accessions containing sequences similar to Tymovirales members to verify the presence of sequence data derived from viral genomes. All steps in the genome mining analysis were performed by a pipeline running on virtual mach...
Defaunation Maps for Tropical Mammals and BirdsNARA Subscribed
Motivation Overhunting is a major driver of defaunation in tropical ecosystems, yet its impacts and spatial extent remain challenging to quantify through conventional remote sensing approaches. Novel modelling frameworks based on quantitative relationships between impacts on wildlife populations and the main drivers of hunting pressure have provided a mean to identify hotspots of defaunation for avian and mammalian communities...
Cell alignment on novel polymeric micro-hollow fiber membranes for neural and musculoskeletal tissue engineeringNARA Subscribed
Precise positioning and alignment of specific cell types, such as those in the central nervous system and the muscular system, is essential for their functional integration, their migration, and proliferation in vivo. Cell alignment in physiologically relevant tissue models and constructs is challenging to reproduce in vitro unless a three-dimensional scaffold is used. This study demonstrates that cell alignment can be guided...
Oropouche fever is an emerging arboviral disease in South America, for which reliable molecular diagnostic specimens throughout the course of infection are essential for surveillance and clinical management. This study aimed to compare the diagnostic performance of RT-qPCR in paired urine and serum samples and to evaluate temporal trends in cycle threshold (Ct) values according to time since symptom onset. A retrospective anal...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the progress. Monitoring insecticide resistance is vital for effective vector control, pa...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A Detailed Characterization of the Whistle Repertoire of Fraser's Dolphins ( Lagenodelphis hosei ) From the Lesser AntillesNARA Subscribed
Fraser's dolphin ( Lagenodelphis hosei ) remains poorly studied due to its elusive behavior, rarity, and preference for deep offshore habitats. While dolphins use frequency‐modulated whistles for communication, detailed acoustic descriptions exist for only a few species. This study provides the first comprehensive characterization of Fraser's dolphin whistle acoustic structure and repertoire, based on recordings from eight gro...