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Wnt signaling inhibitors are under investigation as potential therapies for conditions characterized by upregulated Wnt signaling, such as cancers, hematological disorders, and organ fibrosis. However, because the Wnt pathway is essential for bone homeostasis, its inhibition can adversely affect skeletal health. This review focuses on the bone-related off-target effects of Wnt inhibitors currently in clinical development, spec...
Where does decentralised green nitrogen fit in Africa’s fertiliser resilience strategy?NARA Subscribed
Africa faces recurrent fertiliser shocks because much of its nitrogen supply depends on imported products, fossil energy, and exposed trade routes, while production, product mix, logistics, and farm-gate demand remain poorly aligned. Decentralised green nitrogen production – defined as small-scale nitrogen fertilizer synthesis powered by renewable electricity – could make a major contribution to addressing these challenge, but...
Background Optimized nutrient and water supply is crucial for enhancing crop yields and ensuring environmental sustainability. As a result, sensor-based, high-resolution soil data, which account for in-field soil variability, are becoming increasingly important for effective nutrient and water management. This paper presents research using electrical resistivity methods, which identify variations in electrical soil properties....
An experimental approach to assess the combined effects of multiple stressors on a large vertebrate speciesNARA Subscribed
The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure. The population of bottlenose dolphins in Barataria Bay, Louisiana, experienced long...
The carbon dioxide radical anion as a reductant in water treatment and atmospheric chemistry: a reviewNARA Subscribed
The carbon dioxide radical anion, CO 2 ●− , is a highly reactive radical species involved in the reduction of the CO 2 greenhouse gas, organic synthesis, atmospheric aerosol chemistry, and treatment of halogenated compounds. In recent years, CO 2 ●− has emerged as a strong reductant, or single electron donor. Here we present techniques used to generate CO 2 ●− and we discuss applications to degrading pollutants such as halogen...
Habitat networks for biodiversity are increasingly degraded and fragmented. This study investigates how Swedish municipal landscape managers accommodate biodiversity in urban and peri-urban landscapes, with particular attention to the promotion of ‘wilder landscapes’. We explore their view of nature as related to wilder landscapes too. Drawing on a national survey with responses from 70% of all Swedish municipalities, we analy...