Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...

We propose the wildlife premium mechanism as an innovation to conserve endangered large vertebrates. The performance‐based payment scheme would allow stakeholders in lower‐income countries to generate revenue by recovering and maintaining threatened fauna that can also serve as umbrella species (i.e., species whose protection benefits other species with which they co‐occur). There are 3 possible options for applying the premiu...

Wildlife populations in small, isolated reserves face genetic and demographic threats to their survival. To increase the probability of long‐term persistence, biologists promote metapopulation management, in which breeding subpopulations are protected as source pools. Animals that disperse from the source pools increase the probability of persistence of the metapopulation across the greater landscape. We used a geographic info...

The disappearance of large vertebrates in the tropical belt may be the next biological insult of the global extinction crisis. Large predators and their prey are at particular risk in Asia, where they are threatened by poaching and habitat loss. To facilitate the best use of limited conservation resources, we created an objective, ecology‐based method for identifying priority areas for conservation that incorporates both habit...