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Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolismNARA Subscribed
Summary Glycerol/diol dehydratases (GDH) are enzymes that catalyse the production of propionate from 1,2‐propanediol, and acrolein from glycerol. Acrolein reacts with dietary carcinogenic heterocyclic amines (HCA), reducing HCA mutagenicity, but is itself also an antimicrobial agent and toxicant. Gut microbial GDH activity has been suggested as an endogenous acrolein source; however, there is limited information on the potenti...
Steep clines within a highly permeable genome across a hybrid zone between two subspecies of the E uropean rabbitNARA Subscribed
Maintenance of genetic distinction in the face of gene flow is an important aspect of the speciation process. Here, we provide a detailed spatial and genetic characterization of a hybrid zone between two subspecies of the European rabbit. We examined patterns of allele frequency change for 22 markers located on the autosomes, X ‐chromosome, Y ‐chromosome and mt DNA in 1078 individuals sampled across the hybrid zone. While some...
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