Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correlation with the transvalvular pressure. Materials and Methods Porcine (n = 10) and human (n = 4) mitral valves were mounted in a saddle-shaped annulus clamp, while an in vitro system was utilized to replicate a physiological systoli...

Experimental determinations of trace element distribution between rocks/minerals and fluids at mantle pressures and temperatures have concentrated on eclogite and on fluids containing H 2 O with or without the addition of NaCl. Here we present data for websterite (pyroxenite) coexisting with five different fluids: H 2 O, H 2 O+CO 2 , H 2 O+NaCl, H 2 O+CO 2 +NaCl and H 2 O+NH 3 . All experiments were conducted at 1.5 GPa and 80...

Sustainable groundwater management is key to building resilience to hydrological extremes but remains challenging in data-scarce transboundary river basins. In this study, a transboundary, collaborative, physically based groundwater modelling approach has been developed for the Limpopo River Basin (LRB), which is highly vulnerable to floods and droughts. Monitoring data and model results consistently suggest that prolonged wet...

Ecosystem models are increasingly central to the decision‐making for environmental policy, conservation planning, and climate‐related investments. Yet, the growing reliance on Multi‐Model Ensembles (MMEs) of ecosystem models by practitioners and policymakers, sometimes under tight timelines and imperfect information, has frequently outpaced the scientific rigor required to ensure ensemble reliability. Here, MMEs refer to appro...

The Amazon rainforest is a key component of the Earth system, regulating regional climate, sustaining high biodiversity and carbon stocks. However, it is threatened by climate and land‐use changes. In recent decades, the region has experienced intensified droughts and heatwaves, trends expected to worsen under future warming. In this study, we assess how the timing, length, and spatial distribution of the dry season across the...

Purpose Passive heating has emerged as a potential non‑exercise method to support muscle strength and mass, but its application is limited by inconsistent protocols and unclear dosage and safety guidelines. This study used a Delphi methodology to establish expert consensus on key parameters for passive heating interventions targeting neuromuscular and muscle morphology outcomes. Methods An international panel of academic exper...

Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or endurance exercise performance. The reduced form of CoQ 10 , ubiquinol (UQH 2 ), has greater bioavailability than ubiquinone, but the effects of UQH 2 supplementation on mitochondrial respiratory fu...