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Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...
Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesityNARA Subscribed
Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...
Streptomyces amazonensis sp. nov. isolated from Madeira river sediments with genomic potential for secondary metabolite productionNARA Subscribed
The genus Streptomyces is recognized as a source of secondary metabolites (SMs) with applications in medicine, industry, and agriculture. This study presents the description and characterization of a new Streptomyces species, isolated from sediments of the Madeira River in the Brazilian Amazon. Four strains (CPAA MAD 27, CPAA MAD 39, CPAA MAD 42, and CPAA MAD 51) were obtained from sampling sites distributed along the river. T...
Abandoned mine tailings, rich in potentially toxic elements (PTEs), can be redistributed in urban areas through atmospheric resuspension. This process serves as a dynamic geochemical compartment linking legacy contamination to human exposure. This study investigated the occurrence, oral bioaccessibility, ecological significance, and human health risks of PTEs in urban dust from Boquira, a former Pb–Zn mining district in northe...
Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
Anti-hyperplastic effects of Acmella oleracea flower and leaf extracts in prostate cell lines and in spontaneously hypertensive ratsNARA Subscribed
Benign prostatic hyperplasia (BPH) is a highly prevalent age-associated disorder and a leading cause of lower urinary tract symptoms in men worldwide. Given the limitations of current therapies, there is increasing interest in phytotherapeutic compounds as sources of biologically active agents. Acmella oleracea , a medicinal plant rich in the alkamide spilanthol, has been traditionally associated with urogenital effects; howev...
Monitoring the health of cattle herds is essential for establishing prophylactic measures and reducing their impact on the production chain, especially in regions where beef cattle form the economic base. This study aimed to determine the serological profile of infectious bovine rhinotracheitis (IBR), bovine viral diarrhea (BVD), leptospirosis, toxoplasmosis, and neosporosis in beef cattle slaughtered in a federally inspected...
The assessment of the social impacts of disasters is significant to the decision-making process in public policies for disaster risk reduction. For this reason, the present work proposes to join the Social Impact Assessment (SIA) and Social Life Cycle Assessment (sLCA) methodologies to obtain the most important aspects that the consequences of landslide disasters have on a population to permit a global quantitative measurement...
Modern agriculture faces significant challenges related to the depletion of finite resources used in fertilizer production. In response to this situation, the market has been adapting by developing biofertilizers or organomineral fertilizers, which incorporate an organic fraction into their composition. These fertilizers provide nutrients more gradually, reducing leaching. Studies on this topic are scarce for avocado trees, wh...