Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...

Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...

The genus Streptomyces is recognized as a source of secondary metabolites (SMs) with applications in medicine, industry, and agriculture. This study presents the description and characterization of a new Streptomyces species, isolated from sediments of the Madeira River in the Brazilian Amazon. Four strains (CPAA MAD 27, CPAA MAD 39, CPAA MAD 42, and CPAA MAD 51) were obtained from sampling sites distributed along the river. T...

Low biochar rates (5 Mg ha −1 ) increased bacterial richness and diversity in degraded soil. Biochar origin controlled microbial assembly and niche specialization patterns. Sewage-sludge biochar favored stress-tolerant and metal-adapted bacterial taxa. Cashew bagasse biochar enhanced nitrogen cycling and chemoheterotrophic functions. Network complexity peaked at intermediate biochar doses and declined at high rates. Biochar ha...

This study evaluated the effects of providing 3–15 kg of a soluble and biodegradable biopolymer-based enrichment material (blend of biodegradable polymers and natural fibers) to prepartum sows housed in farrowing crates. Fifteen sows were blocked by body weight and backfat thickness and assigned to three treatments: no enrichment material (CONT), 3 kg of enrichment material (BN3), or 15 kg of enrichment material with added nut...

Anthropogenic habitat transformation has led to population declines and increasing isolation of populations of many species, particularly top predators, where small and fragmented populations often experience limited dispersal and reduced genetic diversity. Jaguars ( Panthera onca ), for example, have lost half of their historical range and most populations outside the Amazon biome are small, isolated and highly threatened. He...

Commercial LTA-type zeolite was evaluated for the adsorption of Mn 2+ and Zn 2+ from aqueous solutions, with emphasis on the relationship between framework properties and adsorption behavior. Despite its very low BET surface area, the zeolite showed rapid and highly efficient uptake of both metal ions, reaching near-equilibrium within the first minute. Kinetic modeling indicated site-controlled adsorption consistent with pseud...

Understanding the drivers of seasonal community assembly in dynamic coastal ecosystems remains a central challenge in marine ecology. A null-model approach was used to investigate whether seasonal changes in the functional diversity of a demersal fish bycatch assemblage in Guanabara Bay, Brazil, are driven by deterministic trait-based filtering or stochastic processes. Four-dimensional functional spaces were constructed from m...

Purpose of Review This review integrates evidence from the literature with network pharmacology tools to explore the decoction’s multitarget potential and provide multilevel insights into its therapeutic role in neuropsychiatric disorders. Recent Findings Neuropsychiatric disorders remain a significant health burden, underscoring the limitations of single-target pharmacotherapies and the urgent need for effective multitarget a...

Abandoned mine tailings, rich in potentially toxic elements (PTEs), can be redistributed in urban areas through atmospheric resuspension. This process serves as a dynamic geochemical compartment linking legacy contamination to human exposure. This study investigated the occurrence, oral bioaccessibility, ecological significance, and human health risks of PTEs in urban dust from Boquira, a former Pb–Zn mining district in northe...

Mangroves are a vital ecosystem for coastal biodiversity and climate regulation but face increasing pressure from agriculture and aquaculture expansion. These threats promote high levels of degradation from direct land use change and hidden impacts from aquaculture effluents rich in nitrogen, phosphorus, and organic compounds. We developed a soil health index to detect different stages of mangrove ecosystem degradation by inco...

The definition of ore and waste blocks is typically made using run-of-mine cut-off grades, calculated with Lane’s formula. This approach implicitly considers metallurgical recovery and yield; however, it overlooks one important ore property: the quality of the product concentrate. This problem can be overcome by leveraging extensive geometallurgical knowledge and this paper presents an example of the gains that can be achieved...

This article presents the first systematic assessment of ethical concerns specific to archaeobotanical research, focusing on principles and values. Conducted by an international group of archaeobotanists, the study used an anonymous online survey to document experiences and perceptions within the archaeobotanical community with the aim of raising awareness, identifying prevalent good practices and noting points for improvement...