F. El Sayed results 158
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This work aims to elucidate the potential of Spirulina platensis (SP) to hinder the accumulation of polyethylene nanoparticles (PE-NPS) in crayfish ( Procambarus clarkii ) and to reduce their detrimental impacts. Four groups (control (only food), PE-NP S (10 mg/L), PE-NPS (10 mg/L) + S. platensis, and only S. platensis in the last group) were studied. The group exposed to PE-NP S only showed: (1) an increase in oxidative stres...
Ursolic Acid (UA), a naturally occurring pentacyclic triterpene, was isolated from Ochrosia elliptica . Polycystic Ovary Syndrome (PCOS) a prevalent endocrine disorder characterized by hyperandrogenism, insulin resistance, and chronic inflammation. In this study, we investigate the role of UA in alleviating the symptoms of PCOS, focusing on its biochemical, hormonal, and histopathological effects in a rat model. Using adult fe...
Neuroprotection by canagliflozin in a Huntington’s disease model: role of HIF-1α and PI3K/AKT signalingNARA Subscribed
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and metabolic dysfunction, largely driven by mitochondrial impairment and defective energy metabolism. Altered signaling through hypoxia-inducible factor-1α (HIF-1α) and PI3K/AKT cascades contributes to neuronal vulnerability. Canagliflozin (Cana), a sodium–glucose cotransporter-2 inhibitor, has shown cognitive benefits in...
Hepatic ischemia/reperfusion (I/R) injury remains a major limitation in liver surgery and transplantation. Amygdalin, a natural glycoside, is known for its antioxidant, anti-inflammatory, and hepatoprotective properties, but its combination with conventional agents is not studied. Accordingly, this study explores a combinatorial approach using a small dose of amygdalin (5 mg/kg) and low-dose infliximab (1.5 mg/kg), a tumor nec...
T his article is aimed at assessing the anti-fibrotic action of plant-based fabricated cerium oxide nanoparticles (CeO 2 NPs). The Carissa carandas aerial parts methanolic extract was utilized to prepare CeO 2 NPs, where the dispersal of particle size distribution and zeta potential value was 61.9 nm and − 18.94 mV, respectively, verifying the successful synthesis of CeO 2 NPs. In rats, CeO 2 NPs were intravenously injected at...
Octreotide attenuates intestinal ischemia/reperfusion mischief in rats through modulation of Nrf2/PRX2/ASK1/JNK signaling pathwayNARA Subscribed
Intestinal ischemia/reperfusion (IIR) is a substantial cause of mortality and morbidity worldwide. Octreotide (OCT) has been proven to be effective against various organ insults. However, the exact mechanism by which it exerts protective effect against IIR is still obscure. Thus, the aim was to unveil the potential role of octreotide in an IIR model and decipher its mechanism of action. The rats were allocated into sham-operat...