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Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...
Mature cow weight (MWT), height (MHT), and body condition score (BCS) are economically important traits that significantly influence cowherd profitability by affecting maintenance feed requirements, which is the largest component of production costs. This study aimed to identify genomic regions, candidate genes, and pleiotropic variants associated with mature cow size traits in American Angus cattle, and to characterize their...
This study aimed to evaluate the exposure of Chelonia mydas (green turtles) inhabiting the south coast of Pernambuco, Northeast Brazil, to essential and toxic elements. Concentrations of Al, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, and Zn were determined in shell, muscle, liver, and kidney samples from 43 individuals using ICP-OES. Element concentrations varied according to tissue type. Specifically, the average concentrations of A...
Feeding ecology of an Amazonian electric knifefish under altered flood‐pulse dynamics caused by hydroelectric dammingNARA Subscribed
This study evaluated the effects of the controlled flood pulse on diet composition, trophic niche breadth and feeding intensity of Archolaemus janeae , an electric knifefish species with a restricted distribution in the Amazon Basin. Monthly samples were collected from December 2020 to November 2021 in the Volta Grande stretch of the Xingu River, and stomach contents of 134 specimens were analysed. The diet was predominantly c...
Sugarcane ( Saccharum officinarum L.) is a strategic crop for the energy sector, but its intensive cultivation requires sustainable management practices. Plant growth-promoting bacteria (PGPB) such as Azospirillum brasilense and Nitrospirillum amazonense are known for their ability to fix atmospheric nitrogen and stimulate growth in grasses. This study evaluated the effects of inoculation with A. brasilense ( Ab ) and N. amazo...
In vivo evaluation of the anti-inflammatory efficacy of liposomes loaded with Echinacea purpurea roots extractsNARA Subscribed
WHO ranked chronic inflammatory diseases as the most significant cause of death. The current therapeutic approach is the constant administration of clinically available anti-inflammatory drugs; however, this strategy presents severe side effects. New entities derived from plants have shown their potential for developing safe and effective therapies. Particularly, Echinacea purpurea extracts have demonstrated strong anti-inflam...
This 2 × 2 factorial study evaluated different progesterone treatment durations and porcine follicle-stimulating hormone (pFSH) presentations for superovulation in acyclic Toggenburg goats. Goats ( n = 56) received short (six days, G6) and long-term (17 days, G17) progesterone intravaginal devices combined with 133 mg (G6 133mg and G17 133mg ) or 250 IU of pFSH (G6 250IU and G17 250IU ) administered in six decreasing doses fro...