Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...

RPGR (Retinitis Pigmentosa GTPase Regulator ) is the main gene involved in X-linked retinitis pigmentosa (RP) and up to 28% of sporadic RP. Pathogenic variants are mostly located in its retina-specific transcript, RPGRorf15 , especially in the terminal exon named open reading frame 15 (ORF15) , which is a highly repeated region. Because of this complex sequence, first- and second-generation short-read sequencing are difficult,...

The search for sustainable protein sources has increased interest in filamentous fungi, however, most studies focus on a limited number of established species. Pleurotus albidus , a basidiomycete native to South America, remains little explored for food applications, particularly regarding the nutritional characterization of its mycelium. In this study, P. albidus was initially cultivated on PDA agar supplemented with yeast ex...