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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Species diversity and competition influence nitrogen resorption efficiency in mixed hardwood plantationsNARA Subscribed
Nutrient dynamics substantially influences forest productivity, yet the influence of competition on these processes in forests is not well understood. Nitrogen is an important limiting nutrient for tree growth, but how canopy nitrogen dynamics are influenced by tree diversity and competition is unclear. Nitrogen-use efficiency is one mechanism suggested to support niche complementarity, promoting increased productivity as dive...
Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant PhenotypesNARA Subscribed
Capillary malformation (CM) is a congenital vascular anomaly that affects the skin, mucosa, eye, and brain. A major obstacle to mechanistic and drug screening studies for CM has been the lack of preclinical models. In this study, we established vascular organoids (VOs) generated through the self-assembly of vascular lineages of endothelial cells and smooth muscle cells differentiated from CM-induced pluripotent stem cells (iPS...
Alzheimer’s disease (AD) is characterized by an insidious onset and complex pathophysiology, necessitating the development of effective strategies for early detection and intervention. This exploratory study aimed to identify differentially expressed genes (DEGs) and disrupted molecular pathways in AD by analyzing blood samples from participants recruited in Valle del Cauca, Colombia, a region with high genetic admixture and p...
This study aimed to identify geographical distribution patterns of the giant short‐tailed river stingray Potamotrygon brachyura and the motoro stingray Potamotrygon motoro in the Uruguay River basin. Data on presence/absence of stingrays were based on fishers' knowledge accessed by interviews through expeditions in Brazil, Argentina and Uruguay. The significance in independent variables (environmental descriptors) of elevation...
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, w...
Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous miceNARA Subscribed
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but...