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Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat modelNARA Subscribed
Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulation and blood pressure control, it may represent an attractive therapeutic target in chronic kidney disease (CKD). We investigated whether this pendrin inhibitor improves metabolic acidosis and salt-sensitive hypertension in the 5...
Stratigraphic evidence of organic carbon depletion in an intensely trawled muddy seabedNARA Subscribed
Understanding the long-term effects of bottom trawling on sedimentary organic carbon (OC) is crucial for assessing its role in carbon cycling and climate regulation. Most studies analyse effects on surface sediments (≤10 cm), leaving impacts on deeper sediments poorly resolved. This study investigates how bottom trawling influences sediment OC density (SCD) and OC content within 0–50 cm of the Western Irish Sea Mud Belt, repre...
Effect of six weeks ubiquinol supplementation on mitochondrial respiratory function and exercise capacity in healthy malesNARA Subscribed
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or endurance exercise performance. The reduced form of CoQ 10 , ubiquinol (UQH 2 ), has greater bioavailability than ubiquinone, but the effects of UQH 2 supplementation on mitochondrial respiratory fu...