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Intestinal inflammation disrupts epithelial integrity, fuels antibiotic resistance, and underlies disorders such as inflammatory bowel disease. Lactobacillus species, established inhabitants of traditional and contemporary fermented foods, are increasingly viewed as bioactive cultures that shape host immunity and support formulation of next-generation functional foods. This review integrates multidisciplinary evidence from in...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cellsNARA Subscribed
Background von Hippel-Lindau (VHL) hereditary cancer syndrome is caused by mutations in the VHL tumor suppressor gene and is characterized by a predisposition to form various types of tumors, including renal cell carcinomas, hemangioblastomas, and pheochromocytomas. The protein products of the VHL gene, pVHL, are part of an ubiquitin ligase complex that tags hypoxia inducible factor alpha (HIF-α) for proteosomal degradation. p...
Innovative resource recovery: converting discarded disposable diapers (D3) into activated carbon using Box–Behnken designNARA Subscribed
This study aims to optimize the production of activated carbon from discarded disposable diapers (D3AC) using Box–Behnken design (BBD) under response surface methodology. Biochar (D3B) was initially produced via carbonization at 900 °C for 90 min under nitrogen flow, followed by physical activation with CO 2 . The BBD model demonstrated strong reliability (R 2 = 0.9972), effectively predicting the influence of activation tempe...
Highly Dynamic Archaeal and Bacterial Communities From the Surface to the Deep in the Atlantic OceanNARA Subscribed
Though archaea are ubiquitous in the oceans, at times present in quantities equal to bacteria, in general, archaea are underreported when compared with bacteria, and little is known about archaeal connectivity in the ocean. Here, we present the first time series data of size‐fractionated archaea with temporal resolution of days across a depth transect in the oligotrophic Atlantic Ocean. Archaeal communities were variable from...
Wind dispersed tree species have greater maximum heightNARA Subscribed
Aim We test the hypothesis that wind dispersal is more common among emergent tree species given that being tall increases the likelihood of effective seed dispersal. Location Americas, Africa and the Asia‐Pacific. Time period 1970–2020. Major taxa studied Gymnosperms and Angiosperms. Methods We used a dataset consisting of tree inventories from 2821 plots across three biogeographic regions (Americas, Africa and Asia‐Pacific),...