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Climate change is an environmental emergency threatening species and ecosystems globally. Oceans have absorbed about 90% of anthropogenic heat and 20%–30% of the carbon emissions, resulting in ocean warming, acidification, deoxygenation, changes in ocean stratification and nutrient availability, and more severe extreme events. Given predictions of further changes, there is a critical need to understand how marine species will...
Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null ( Tert −/− ) mice with critically short telomeres, we investigated the effect of NAD supple...
Replacement of microsatellite markers by imputed medium-density SNP arrays for parentage control in German warmblood horsesNARA Subscribed
In horses, parentage control is currently performed based on an internationally standardized panel of 17 microsatellite (MS) markers comprising 12 mandatory and five optional markers. Unlike MS, single nucleotide polymorphism (SNP) profiles support a wider portfolio of genomic applications, including parentage control. A transition to SNP-based parentage control is favorable, but requires additional efforts for ensuring genera...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Genetic and genomic characterization followed by single-step genomic evaluation of withers height in German Warmblood horsesNARA Subscribed
Reliability of genomic predictions is influenced by the size and genetic composition of the reference population. For German Warmblood horses, compilation of a reference population has been enabled through the cooperation of five German breeding associations. In this study, preliminary data from this joint reference population were used to genetically and genomically characterize withers height and to apply single-step methodo...
Intestinal and hepatic effects of iron oxide nanoparticlesNARA Subscribed
Iron oxide nanoparticles gain increasing attention due to their broad industrial use. However, safety concerns exist since their effects on human cells are still under investigation. The presence of iron oxide nanoparticles in the food pigment E172 has been shown recently. Here, we studied four iron oxide nanoparticles, one food pigment E172 and the ionic control FeSO 4 regarding dissolution in biological media, uptake and tra...
Phenology and productivity in a montane bird assemblage: Trends and responses to elevation and climate variationNARA Subscribed
Climate variation has been linked to historical and predicted future distributions and dynamics of wildlife populations. However, demographic mechanisms underlying these changes remain poorly understood. Here, we assessed variation and trends in climate (annual snowfall and spring temperature anomalies) and avian demographic variables from mist‐netting data (breeding phenology and productivity) at six sites along an elevation...
Understanding the biophysical mechanisms that shape variability in fisheries recruitment is critical for estimating the effects of climate change on fisheries. In this study, we used an Earth System Model ( ESM ) and a mechanistic individual‐based model ( IBM ) for larval fish to analyze how climate change may impact the growth and survival of larval cod in the North Atlantic. We focused our analysis on five regions that span...
Postfire response of North American boreal forest net primary productivity analyzed with satellite observationsNARA Subscribed
Fire is a major disturbance in the boreal forest, and has been shown to release significant amounts of carbon (C) to the atmosphere through combustion. However, less is known about the effects on ecosystems following fire, which include reduced productivity and changes in decomposition in the decade immediately following the disturbance. In this study, we assessed the impact of fire on net primary productivity (NPP) in the Nor...