Constitutional mismatch repair deficiency (CMMRD) is a rare and likely the most penetrant cancer predisposition syndrome caused by biallelic germline variants in a mismatch repair gene. Patients typically develop a spectrum of malignancies, including brain tumors, gastrointestinal cancers, and hematological neoplasms within the first two decades of life. Since its initial description in 1999, two international consortia, the I...

Snakebite envenomation is a neglected tropical disease and incidents of the pit viper Lachesis muta cause hemorrhage, muscle damage, blood coagulation disturbances, and even death; the proteases and phospholipase A 2 (PLA 2 ) of snake venoms contribute to such toxic effects. This work evaluated the inhibitory effect of commercial fucoidans from two species of brown seaweeds Fucus vesiculosus (FVF) and Undaria pinnatifida (UPF)...

United States and Canadian governments have responded to legal requirements to reduce human‐induced whale mortality via vessel strikes and entanglement in fishing gear by implementing a suite of regulatory actions. We analyzed the spatial and temporal patterns of mortality of large whales in the Northwest Atlantic (23.5°N to 48.0°N), 1970 through 2009, in the context of management changes. We used a multinomial logistic model...