Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasing global health concern with limited effective therapies. Silymarin exhibits hepatoprotective properties, but its utility is limited by poor bioavailability. This study evaluated a novel phytosomal silymarin formulation co-administered with piperine and lecithin, compared to fenofibrate, in an oxytetracycline-induced MASLD rat model. Twenty-five ma...

The Marmarica Formation in the north Western Desert (NWD) of Egypt is predominantly composed of Middle Miocene carbonate rocks. A detailed microfacies and paleoenvironmental analysis was conducted on six representative surface sections extending from the Siwa to Matruh areas: Dakrur, North Siwa (NS), Siwa-Matruh 1 (SM1), Siwa-Matruh 2 (SM2), Abu Khrait, and Agiba. Field observations and lithological data indicate that the Marm...

Genetic causes of steroid-resistant-nephrotic-syndrome (SRNS) represent a rapidly growing number of monogenic diseases. The reported diagnostic yield of various studies applying genetic panels and exome-sequencing to diagnose SRNS is usually < 30%. We performed genome-sequencing in a cohort of Egyptian SRNS patients. We recruited 47 SRNS patients belonging to 41 unrelated families [28 males/19 females; median (range): 6 (0.5–2...