Fatma Mostafa results 44
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Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in ratsNARA Subscribed
Rationale One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cognitive dysfunction (chemobrain). This is primarily triggered by oxidative stress and inflammation. Captopril, an angiotensin-converting enzyme inhibitor, has been reported as a neuroprotective agent owing to its antioxidant and anti-inflammatory effects. Objective We examined the possible neuroprot...
Alzheimer’s disease (AD) is a globally prevalent form of dementia that impacts diverse populations and is characterized by progressive neurodegeneration and impairments in executive memory. Although the exact mechanisms underlying AD pathogenesis remain unclear, it is commonly accepted that the aggregation of misfolded proteins, such as amyloid plaques and neurofibrillary tau tangles, plays a critical role. Additionally, AD is...
Statistical analysis of the variability of reactive trace gases (SO2, NO2 and ozone) in Greater Cairo during dust storm eventsNARA Subscribed
The data of 17 air quality monitoring stations of Greater Cairo are used to perform a statistical analysis aiming to detect any heterogeneous surface effects of mineral dust on the distribution of reactive trace gases (SO 2 NO 2 , and ozone) in. After a thorough quality check, the methodology consisted of i) selecting representative stations by agglomerative hierarchical clustering, ii) identifying dust events based on PM 10 m...
Background Vascular calcification (VC) is a major predictor of cardiovascular diseases that represent the principal cause of mortality among type-2 diabetic patients. Accumulating data suggest the vital role of some microRNAs on vascular calcification as an epigenetic regulator. Thus, we assessed herein, the role of serum miR-433-3p in vascular calcification in type-2 diabetic patients. Methods Twenty healthy subjects (control...
Growing evidence supports the role of the gut-kidney axis and persistent mitochondrial dysfunction in the pathogenesis of diabetic nephropathy (DN). Ulinastatin (UTI) has a potent anti-inflammatory effect, protecting the kidney and the gut barrier in sepsis, but its effect on DN has yet to be investigated. This study aimed to assess the potential mitigating effect of UTI on DN and investigate the possible involvement of gut-ki...