Disentangling the contributions of local adaptation and neutral geographic differentiation in shaping spatial genomic variation is central to understanding how populations evolve across heterogeneous environments. In the Gulf of California (GoC), the interaction between pronounced environmental gradients and complex oceanographic circulation creates a challenging scenario for determining whether adaptive divergence or neutral...

Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...

Urbanization, characterized by increased temperatures and habitat fragmentation, poses significant threats to reptile populations. Temperature threatens reptile populations, reducing the available hours of activity; however, the deleterious effects of temperature on sperm integrity have been scarcely investigated. This study investigates the impact of urbanization on the sperm fertility of the mesquite lizard ( Sceloporus gram...

Global warming is threatening ectotherms, with strong repercussions on their population dynamics. Body temperature in ectotherm reptiles is crucial to perform all their biological functions, which are maximized within a narrow interval. When faced with new or adverse thermal conditions, reptiles will respond with distributional changes, behavioural adjustments to maintain their internal temperature, or by adapting to the new e...

A single individual of Ariidae was captured in 2022 in the Palestinian waters off the Gaza Strip, eastern Mediterranean. A comprehensive description of the morphological and meristic characters of the specimen was conducted. Molecular identification was performed through sequence analysis of the Cytochrome Oxidase subunit I (COI). The specimen was identified as Ariopsis felis, both morphologically and genetically. The natural...

Aim Squamate fitness is affected by body temperature, which in turn is influenced by environmental temperatures and, in many species, by exposure to solar radiation. The biophysical drivers of body temperature have been widely studied, but we lack an integrative synthesis of actual body temperatures experienced in the field, and their relationships to environmental temperatures, across phylogeny, behaviour and climate. Locatio...