Cerebellar ataxia, neuropathy, vestibular-areflexia syndrome (CANVAS) has been linked to biallelic intronic repeat-expansions in RFC1 . Video-head-impulse testing (vHIT) offers a quantitative assessment of the angular vestibulo-ocular reflex (aVOR) of all three canals. We evaluated patterns of peripheral-vestibular impairment, its change over time and evaluated correlations with other parameters. PubMed/Embase were searched fo...

Purpose Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are available for real-time monitoring of moisture content by, e.g., near-infrared spectroscopy (NIRS), which requires additional installation and c...

There is a growing societal, economic, and political demand to translate available data on regional climate change into sector-specific, practice-oriented, and user-friendly information. The study presents a demand-driven approach to specify the impacts of regional climate change on agriculture, viticulture, and fruit and vegetable growing in Lower Franconia, southern Germany, a region with heterogeneous topography, diversifie...