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NARA Subscribed1
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Springer Nature1
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Naunyn-Schmiedeberg's Archives of Pharmacology1
Publication Year
20251
Fern Findlay-Greene results 1 · Newest (Page 1/1, per page 25)
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Author: Fern Findlay-Greene ×Clear All Filters
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Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophagesNARA Subscribed
Naunyn-Schmiedeberg's Archives of Pharmacology · 2025 · Vol. 398 · Issue 4 · Springer
Connan D. Masson; Fern Findlay-Greene; Filipa Henderson Sousa; Paul Henderson; Jennifer A. Fraser; Peter G. Barlow; Craig Stevens
Activating autophagy may be therapeutically beneficial, and we have previously shown that azathioprine (AZA), an immunomodulatory drug, induces autophagy. Here, we evaluated the induction of autophagy by the thiopurines AZA, mercaptopurine (6-MP) and thioguanine (6-TG) in THP-1 macrophages and investigated the mechanism of action in the context of this cellular process. The cytotoxicity of thiopurines was evaluated using an LD...
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